Mining personal, dense, dynamic data clouds to enhance health and drive discovery
Nathan Price, Professor & Associate Director of the Institute for Systems Biology

May. 30, 2018, 3:30 p.m., Physics/Astronomy Auditorium (PAA), A102

[Watch a recording of this seminar on YouTube, and find slides here.]


Healthcare is becoming more proactive and data-rich than anything before possible. Lee Hood and I have recently launched a data-rich wellness project that integrates genomics, proteomics, metabolomics, microbiomes, clinical chemistries and wearable devices of the quantified self to monitor wellness and disease.

These resulting personal, dense, dynamic data (PD3) clouds enable the creation of a field we term “scientific wellness” that aims to help individuals take informed actions to enhance their wellness and help reduce their risk for disease — informed by PD3 clouds. In essence, scientific wellness becomes a key to understanding disease because it provides a framework in which to detect the earliest transition states in a data-rich context. Analyses of these data — individually and in aggregate — will enable us to identify scientifically-validated metrics for wellness, see early warning signs of disease, and develop approaches to reverse disease in its early stages.

I will present results from our proof-of-concept pilot study in a set of 108 individuals (the Pioneer 100 study) as well as data from thousands of subsequent individuals that have been profiled to date. I will show how the interpretation of these data led to actionable findings for individuals to improve health and reduce risk drivers of disease, and how they are giving us insights into human biology. I will also give views of how this endeavor relates to the future of health and big data analyses for biology and medicine.


A photo of Nathan PriceDr. Nathan Price is a professor and associate director of the Institute for Systems Biology in Seattle where he co-directs with Lee Hood the Hood-Price Integrated Lab for Systems Biomedicine. He is also affiliate faculty at the University of Washington in the Departments of Bioengineering, Computer Science & Engineering, and Molecular & Cellular Biology.

He is co-founder and on the board of directors of Arivale, a scientific wellness company that was named as GeekWire’s 2016 startup of the year. He was the recipient of early career awards from the National Institutes of Health, the National Science Foundation, American Cancer Society, the Roy J. Carver Charitable Trust, and Genome Technology.

He was also named as a Camille Dreyfus Teacher-Scholar, and received the 2016 Grace A. Goldsmith Award for his work in pioneering “scientific wellness”. He serves on numerous advisory boards including Roche (Personalized Medicine division), Providence St. Joseph Health, Habit, Trelys, Novo Nordisk Foundation Center for Biosustainability, Science Translational Medicine and Cell Systems.