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TZID:America/Los_Angeles
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BEGIN:VEVENT
UID:87@escience.washington.edu
DTSTART:20240502T003000Z
DTEND:20240502T012000Z
DTSTAMP:20240426T161227Z
URL:https://escience.washington.edu/events/uw-data-science-seminar-jihoon-
 lee/
SUMMARY:UW Data Science Seminar: Jihoon Lee
DESCRIPTION:\n\nPlease join us for a UW Data Science Seminar event on Wedn
 esday\, May 1st from 4:30 to 5:20 p.m. PDT. The seminar will feature Jihoo
 n Lee\, an MD-PhD candidate in the Medical Scientist Training Program at t
 he UW.\n\nThe seminar will be held in the Physics/Astronomy Auditorium (PA
 A)\, Room A118 – campus map.\n\n\n“Integrated analysis of plasma and 
 single immune cells uncovers metabolic changes in individuals with COVID-1
 9”\nAbstract:\nA better understanding of the metabolic alterations in im
 mune cells during severe acute respiratory syndrome coronavirus 2 (SARS-Co
 V-2) infection may elucidate the wide diversity of clinical symptoms exper
 ienced by individuals with coronavirus disease 2019 (COVID-19). Here\, we 
 report the metabolic changes associated with the peripheral immune respons
 e of 198 individuals with COVID-19 through an integrated analysis of plasm
 a metabolite and protein levels as well as single-cell multiomics analyses
  from serial blood draws collected during the first week after clinical di
 agnosis. We document the emergence of rare but metabolically dominant T ce
 ll subpopulations and find that increasing disease severity correlates wit
 h a bifurcation of monocytes into two metabolically distinct subsets. This
  integrated analysis reveals a robust interplay between plasma metabolites
  and cell-type-specific metabolic reprogramming networks that is associate
 d with disease severity and could predict survival.\n\n&nbsp\;\n\n\nBiogra
 phy: Jihoon Lee is an MD-PhD student at the UW. Jihoon’s research intere
 sts are in development of adoptive cell therapies for precise targeting of
  cancer\, and the use of systems biology to understand and improve these t
 herapies. His work has focused on integrated analyses of cell functional\,
  phenotypic\, and various layers of molecular data to infer critical molec
 ular changes that affect cell behavior. Jihoon was previously at Caltech\,
  where he obtained a BS in Bioengineering. He recently completed his PhD t
 raining and is now finishing up his MD training as part of the UW Medical 
 Scientist Training Program.\n&nbsp\;\nThe UW Data Science Seminar is an 
 annual lecture series at the University of Washington that hosts scholars 
 working across applied areas of data science\, such as the sciences\, engi
 neering\, humanities and arts along with methodological areas in data scie
 nce\, such as computer science\, applied math and statistics. Our presente
 rs come from all domain fields and include occasional external speakers fr
 om regional partners\, governmental agencies and industry.\n&nbsp\;
LOCATION:Physics/Astronomy Auditorium\, room A118\, Seattle\, WA\, 
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Seattle\, WA\, ;X-APPLE-RAD
 IUS=100;X-TITLE=Physics/Astronomy Auditorium\, room A118:geo:0,0
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